The Clayton Foundation for Research and its supporting entities currently conduct and fund medical research programs in the following areas:
Cancer
- Tumor targeting toxins
- Engineered proteases
- Fc engineered aglycosylated antibodies
- Immuno-oncology: targeting novel-intrinsic PD Pathways
- Novel therapeutic strategies for liver cancer
- Novel microproteins for cancer treatment
- SmartLaser Knife for brain cancer treatment
- Drug Delivery systems for treating solid tumors
CNS, Opthalmology
- Stem cell therapy for Parkinson’s Disease
- Early detection and treatment of glaucoma
- Electroceutical therapies
- Reprogramming neural circuits of anxiety
- Neurotensin gates valence-specific plasticity of associative learning
- New mechanisms and therapeutics for brain injury
Metabolic Diseases
- Microbiome in obesity and diabetes
- Molecular switches in glucose control
Infectious Diseases
- Vaccines and diagnostics for Ehrlichioses
- Drug discovery program to host-based antiviral targets
Autoimmune, Inflammation
- Engineered proteases
- Fc engineering of aglycosylated antibodies
- Bifunctional molecules for rapid protein clearance from blood
Cardiology
- OCT-TPL diagnostics of human vascular plaques to predict heart attacks and strokes
- SmartWire for traversing CTOs
Women's Health
- SmartIlluminator for detection and treatment of endometriosis
- Microbiome in post-menopausal osteoporosis and obesity
Dermatology
- Filaggrin for flg-deficient genetic dermatological diseases