Research Projects

The Clayton Foundation for Research and its supporting entities currently conduct and fund medical research programs in the following areas:


  • Tumor targeting toxins
  • Engineered proteases
  • Fc engineered aglycosylated antibodies
  • Immuno-oncology: targeting novel-intrinsic PD Pathways
  • Novel therapeutic strategies for liver cancer
  • Novel microproteins for cancer treatment
  • SmartLaser Knife for brain cancer treatment
  • Drug Delivery systems for treating solid tumors

CNS, Opthalmology

  • Stem cell therapy for Parkinson’s Disease
  • Early detection and treatment of glaucoma
  • Electroceutical therapies
  • Reprogramming neural circuits of anxiety
  • Neurotensin gates valence-specific plasticity of associative learning
  • New mechanisms and therapeutics for brain injury

Metabolic Diseases

  • Microbiome in obesity and diabetes
  • Molecular switches in glucose control

Infectious Diseases

  • Vaccines and diagnostics for Ehrlichioses
  • Drug discovery program to host-based antiviral targets

Autoimmune, Inflammation

  • Engineered proteases
  • Fc engineering of aglycosylated antibodies
  • Bifunctional molecules for rapid protein clearance from blood


  • OCT-TPL diagnostics of human vascular plaques to predict heart attacks and strokes
  • SmartWire for traversing CTOs

Women's Health

  • SmartIlluminator for detection and treatment of endometriosis
  • Microbiome in post-menopausal osteoporosis and obesity


  • Filaggrin for flg-deficient genetic dermatological diseases