Pipeline

Research at the Clayton Foundation has led to several FDA approved drugs, medical devices and diagnostic assays along with the following pipeline in development by our licensees.

Clinical Pipeline

eli-cel (Lenti-D)

Indication: Cerebral ALD

Phase II / III - accelerated assessment of MAA

beti-cel (LentiGlobin)

Indication: Beta Thalassemia

Phase III

LentiGlobin

Indication: Sickle Cell Disease

Phase II / III

PEC-Encap VC-01

Indication: All T1 Diabetes

Phase I / II

PEC-Direct VC-02

Indication: High-risk T1 Diabetes

Phase I / II

PEC-QT

Indication:All T1 and T2 Diabetes

Preclinical

Oral Vimo-001

Indication: Solid Tumors

Phase I

Pre-Clinical Pipeline

RT-200

Indication: Type II Diabetes

Advanced Preclinical

RT-300

Indication: Congestive Heart Failure

Preclinical

RT-400

Indication: Acute decompensated heart failure

Preclinical

GrB-Fc-SD1

Indication: Mesotheliomas & Pancreatic Cancers

Preclinical

Grb-Fc-IT4

Indication: Breast, Lung, Melanoma Cancers

Preclinical

Grb-Fc-4D5

Indication: Breast, GEJ Ca Cancers

Preclinical

Grb-Fc-HMEL

Indication: Melanoma, Breast Cancers

Preclinical

Early Stage Pipeline

JamC mAb

Indication: B Cell Lymphomas

Animal in vivo POC

Olfml3 mAb

Indication: Metastatic breast cancer

Animal in vivo POC

SrpX2 mAb

Indication: TBD

Animal in vivo POC

DHS Fc Domain

Fc domain for antibody half-life extension

Animal POC (Download PDF)

GrB platform

Platform technology potent elimination of unwanted cells

Animal POC (Download PDF)

SmartLaser Wire and SmartKnife

Applications: Chronic Total Occlusions (CTOs) and Brain tumors

Prototype development

Filaggrin-RMR

Indication: Flg -/- dermatological disorders

Animal in vivo POC (Download PDF)

Fc domains

Platform: Various applications

Research (Download PDF)

Stem Cell Safety Switch

Indication: Stem Cell Therapy in CNS (PD…)

Preclinical (Download PDF)

HI P. Goldsteinii

Indication: Osteoporosis and Obesity

Preclinical (Download PDF)

R1-MMAE

Indication: Ovarian cancer

Animal in vivo POC

YESS-KI

Diagnostic for Kinase Inhibitor Therapy

Research (Download PDF)

Kinase Cell Lines

For in vitro cell based kinase assays

Research (Download PDF)

Phase Agnostic Stimulation

Closed-loop bioelectric therapy

Research (Download PDF)

YESS

Discovery and Engineering of therapeutic proteases

Research (Download PDF)