Pipeline

Research at the Clayton Foundation has led to several FDA approved drugs, medical devices and diagnostic assays along with the following pipeline in development by our licensees.

Clinical Pipeline

Lenti-D

Indication: Cerebral ALD

Phase II / III

LentiGlobin BB305

Indication: Beta Thalassemia

Phase III

LentiGlobin BB305

Indication: Sickle Cell Disease

Phase I / II

bb2121 BCMA

Indication: Multiple Myeloma

Breakthrough Designation

OXB-201

Indication: AMD

Phase I Completed

OXB-202

Indication: Corneal Graft

Phase I / II

PEC-Encap VC-01

Indication: T1 and Insulin-requiring T2 Diabetes

Phase I / II

PEC-Direct VC-02

Indication: High-risk T1 Diabetes

Phase I / II

Oral Vimo-001

Indication: Solid Tumors

Phase I

Pre-Clinical Pipeline

RT-200

Indication: Type II Diabetes

Advanced Preclinical

RT-300

Indication: Congestive Heart Failure

Preclinical

RT-400

Indication: Acute decompensated heart failure

Preclinical

MRT-101 – Grb-Fc-IT4

Indication: Breast, Lung, Melanoma Cancers

Preclinical

MRT-201 – Grb-Fc-4D5

Indication: Breast, GEJ Ca Cancers

Preclinical

MRT-301 – Grb-Fc-HMEL

Indication: Melanoma, Breast Cancers

Preclinical

GrB-Fc-SD1

Indication: Mesotheliomas & Pancreatic Cancers

Preclinical

Dengue Tetra Vaccine

Indication: Dengue Fever

IND Package

Chik Vaccine

Indication: Chikungunya

Preclinical

Early Stage Pipeline

JamC mAb

Indication: B Cell Lymphomas

Animal in vivo POC

Olf mAb

Indication: Metastatic breast cancer

Animal in vivo POC

SrpX2 mAb

Indication: TBD

Animal in vivo POC

Zika Vaccine

Indication: Zika

Candidate Selection

SmartKnife

Applications: Chronic Total Occlusions (CTOs), Endometriosis, Brain tumors

Prototype development

CRFR1 antagonist

Indication: AD and related tauopathies

Candidate Selection

Grp78 mAb

Indication: Ovarian cancer

Candidate Selection

Fillagrin-RMR

Indication: Severe Icthyosis Vulgaris

Animal in vivo POC

Fc domains

Platform: Various applications

Research

Stem Cell Safety Switch

Indication: Stem Cell Therapy in CNS (PD…)

Preclinical

E. canis Vaccine

Indication: Ehrlichiosis Canis

Research